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No. They aren't the same species. Different looking dogs can breed because they're still the same species. Horses and donkeys can breed because they're ALMOST the same species, but their offspring are always infertile. Rabbits and guinea pigs are both rodents but aren't the same species at all, so they can't breed.
There is a difference between mate and breed, I suppose. My psychotic cat tries to mate with a blanket, but he obviously couldn't breed with it (I.e. have babies). So maybe they might get on very well, but they won't have babies.
Did you want them to mate, or would you rather they didn't?
A horse and a donkey are different species, but they can breed to make a mule. A horse and zeebra make a Zorse (I have seen one). A lion and tiger breed together make a liger. These breeding are due to the 2 parents breeding are both decendants of the same evolutionary branch. They all are 99.999% the same (Genetically), so breeding is possible. But the resulting offspring end up being sterile, and are unable to breed themselves. So this is possible, and has happened before in labs.
My source: Life expierence and the
History Channel: Monster (Russian scientist tried to breed chimps with humans)
But then how did a rabbit and a cat breed being called a cabbit




Can a rabbit mate with a guinea pig?
can a rabbit mate with a ginnypig?